It interacts with basic groups of proteins, forms salts and coagulates them. Persistence and degradability picric acid, saturated persistence and degradability not established. Picric acid safety guidelines picric acid is a trinitroaromatic compound frequently found in forensic and histology laboratories as a staining and fixative agent. Material safety data sheet picric acid, saturated 3 lined metal and label for disposal.
Acetone is not expected to be toxic to fish but picric acid is. Picric acid, wet, with not less than 10% water undergoes vigorous reactions with both oxidizing or reducing agents. Picric acid is biodegradable and not expected to accumulate in the environment. Picric acid safety guidelines concordia university. It must be kept wet with water usually 30% or more because the dry solid is explosive. Picric acid is also used in the analytical chemistry of metals, ores, and minerals. Recommended use and restrictions on use use of the substancemixture.
Jun 04, 2019 van giesons stain topic van giesons stain is a mixture of picric acid and acid fuchsin. Contain if possible, prevent runoff into drains and sewers. Information on picric acid stanford environmental health. Section 1 chemical product and company identification. Show this safety data sheet to the doctor in attendance. Each fact sheet serves as a quick and easy to understand guide. The complexes with aromatic hydrocarbons, etc, are in general not so sensitiv the frictionsensitivecalcium salt. Dry mixtures of picric acid and aluminum powder are inert, but addition of water causes ignition after a delay depending upon the quantity added. Material safety data sheet biopacific diagnostic inc. Two new anthracenefunctionalized fluorescent trisimidazolium salts have been synthesized, characterized, and proven to be selective sensors for picric acid, which is a common. An explosive mixture results when the aqueous solution crystallizes.
Use protective clothing and breathing equipment appropriate for the surrounding fire. Page 3 of 8 msds phosphoric acid, 85% material is toxic, infectious or corrosive. Swallowing picric acid may cause severe poisoning, headache, dizziness, nausea, vomiting and diarrhea. Seastar chemicals inc msds perchloric acid page 3 of 5 personal protective equipment eyes. Picric acid sds msds sheet, suppliers and manufacturers represantative cas no 88891, einecs ec number xxxxxxx, molecular weight. Wear appropriate protective face shield and eyeglasses or chemical safety goggles as described by. Dry picric acid is relatively sensitive to shock and friction, so laboratories that use it store it in bottles under a layer of water, rendering it safe. In normal use conditions and in its original form, the product itself does not involve any other risk for health and the environment. If handling picric acid contained in a jar, gently tilt bottle to see if there are any crystals. Purchases of picric acid should be restricted to the smallest practical quantities. In 1859, german chemist friedrich august kekule determined the molecular structure of picric acid. Very hazardous in case of skin contact irritant, of eye contact irritant.
Dispose of the picric acid containers within 2 years from date received. It dissolves in water to form a solution with low ph ph 2. Do not let dry picric acid crystals form in container or on the cap threads of container. The dry compound can explode if shocked or exposed to heat. From the 1850s onwards, it was usually prepared by the nitration of phenol extracted from coal tar, a product of the coke and coal gas industry. Information on picric acid for use in responding to chemical incidents. Picric acid no no none section xii ecological information environmental fate. Do not place in metal containers or containers with metal lids. Hsms84 response to dehydrated picric acid procedure page 3 of 5 version 01. Picric acid, wetted 88 89 1 ec50 other aquatic organisms 1 240 mgl algae. Cdc niosh pocket guide to chemical hazards picric acid. Page 1 of 2 picric acid university of michiganflint.
Hazardous in case of skin contact irritant, of eye contact irritant. The internal elastic lamina or internal elastic lamella is a layer of elastic tissue that forms the outermost part of the tunica intima of blood vessels. Picric acid should be disposed as a hazardous waste within 2 years of initial receipt. Picric acid material safety data sheet cas no 88891 sdsmsds. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Working safely with picric acid university of british. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. A meta description is an html tag in the html code of your website, which allows you to customize a section of text that describes the page itself. Contact ehs for disposal for wet solutions of picric acid only. If inhaled if breathed in, move person into fresh air. Normally, water is added to picric acid, otherwise the dry material is a touch sensitive explosive. Section xiii disposal considerations local governments may restrict the amounts of picric acid.
Make sure that any picric acid disposed of still has some water content. Jul 01, 2014 information on picric acid for use in responding to chemical incidents. Oxidative destruction of picric acid in aqueous media by fentons reagent article pdf available in environmental engineering science 262. Picric acid, wetted 88 89 1 persistence and degradability not readily biodegradable in water.
Picrate salts are formed by the reaction of picric acid with any of the following. It forms salts picrates rather easily and many of its salts are more sensitive explosives than picric acid itself. Incompatible with strong oxidizing agents, bases, most common metals, ammonia,strong reducing agents. Glass or plastic bottles are required, as picric acid can easily. Pdf oxidative destruction of picric acid in aqueous media. Picric acid and acetone are biodegradable and not expected to accumulate in the environment. Material safety data sheet msds phosphoric acid, 85%. If they do, the acid is dry and capable of explosioncontact personnel trained in.
Picric acid can be detonated by extreme heat, a blasting cap, or an electric charge. Picric acid forms salts with many metals some of which are rather sensitive nickel, copper, etc. First aid measures general advice consult a physician. Picric acid is toxic if swallowed, inhaled, or absorbed through the skin. Dispose of by incineration following federal, state. Hydrochloric acid revision date 25apr2019 stability stable under normal conditions.
Picric acid sds msds sheet, material safety data sheet. Picric acid material safety data sheet cas no 88891. As a convenience from avantik, below is a list of sds sheets which are available for download as pdf files. Safe handling of picric acid university of wisconsinmadison. Dry mixtures of picric acid and aluminum powder are inert, but the addition of water causes ignition after a. The salts formed with ammonia and amines, and the molecular complexes with aromatic hydrocarbons, etc, are in general not so sensitive. Fixation with picric acid gives a bright stain, but there might be a loss of nucleic acids due to the low ph of the solution. H201, h301, h331, h311 60 picric acid is an irritant of the eyes, skin, and mucous membranes. Handling picric acid university of california, san diego.
Picric acid may detonate if allowed to dry completely. It plays a role in how your page is seen by search engine crawlers, and how it appears in serps. The complexes with aromatic hydrocarbons, etc, are in general not so sensitive the frictionsensitive calcium salt. Picric acid was the first high explosive nitrated organic compound widely considered suitable to withstand the shock of firing in conventional artillery. Identification of the substancemixture and of the companyundertaking 1. Picric acid, when in contact with metals, can form sensitive metal picrates. Material safety data sheet picric acid, wetted with at. British chemist peter woulfe discovered picric acid in 1771. My textbook says nowadays picric acid is prepared by treating phenol first with concentrated sulfuric acid which converts it to phenol2,4disulfuric acid and then with concentrated nitric acid to get 2,4,6trinitrophenol my question. Safety data sheet 116920 picric acid moistened with 30% water.
Contact between picric acid and concrete floors leads to the formation of explosionsensitive salts, such. Why is this a better method than simply treating phenol with concentrated nitric acid to obtain picric acid. Occupational exposure limits for chemical substances, occupational health and safety regulation 29697, as amended components type value picric acid cas 88891 twa 0. The name comes from the greek word pikros which means bitter, as picric acid. A shockinsensitive explosive compound that forms shocksensitive explosive salts with metals such as lead is too unwieldy for most usual applications.
Picric acid was formulated by peter woulfe, a british chemist, in 1771, although glauber is claimed to have written about it in 1742. If you decide to dispose of your wet picric acid, some options are available. Potential hazards the most serious hazard associateddamage. Contact of picric acid with concrete floors may form the frictionsensitive calcium salt. It was not until the 1840s that picric acid became widely used as a yellow dye. Fixation with picric acid gives a bright stain, but there might be a loss of nucleic acids. Every couple months, an article appears in the local paper about a bomb disposal team removing picric acid that was found in a laboratory. Safety data sheet 116920 picric acid moistened with. Picric acid forms salts with many metals some of which are rather sensitive to heat, friction, or impact, e. Health hazards acute oral toxicity of picric acid is high. Weve included the most sought after safety data sheets, and the database just keeps growing. This file may not be suitable for users of assistive technology. Do not induce vomiting unless directed to do so by medical per sonnel. Burns if ignited by a flame and continues to burns quietly if the quantity is small or, if large, is thinly spread over an area.
Dry mixtures of picric acid and alum ignition after a delay dependent upon the quantity added. High temperatures, mechanical shock, ignition sources. Trinitrophenol, wetted or picric acid, wetted with not less than 30% water by mass appears as a paste or slurry consisting of the yellow crystalline solid mixed with water. High doses may cause damage to red blood cells, kidneys and liver. Picric acid trinitrophenol or 2,4,6 trinitrophenol explosion hazard when dry cas number 88891 date occurred 23rd may 2007 what happened a disposal request was received for a 500 gram jar of picric acid that had dried out. Picric acid can be found on the following state righttoknow lists. Jul 29, 2011 picric acid was formulated by peter woulfe, a british chemist, in 1771, although glauber is claimed to have written about it in 1742. Picric acid is in the same family of nitroaromatic explosives as trinitrotoluene tnt. Aug 24, 2019 van giesons stain is a mixture of picric acid and acid fuchsin. Picric acid is a skin sensitizer, resulting in allergic contact dermatitis dermatitis caused by direct skin exposure to picric acid. Incompatible materials metals, strong oxidizing agents, bases, sodium hypochlorite, amines, fluorine, cyanides. Picric acid is a highpowered explosive when allowed to dehydrate. The name comes from the greek word pikros which means bitter, as picric acid has a bitter taste it is toxic. Picric acid acetone solution page 5 health 2 fire hazard 3 reactivity 2 specifichazard health 2 3 2 health flammability physical hazard personal protection 16.
It is no longer used as an explosive because of this type of reaction. Guidance document safe handling of picric acid this is a brief summary. Picric acid vapor can cause tissue damage to areas it contacts. If possible, eliminate solid picric acid from your inventory by purchasing premixed stains or a 1% solution for use in stain preparation. Fluorescent trisimidazolium sensors for picric acid. Identification of the substancemixture and of the companyundertaking. Your new online msds binder is a place for you to store the material safety data sheets.
Our msds database is an easy to use, do it yourself tool, and best of all. Material safety data sheet west liberty university. Safe handling of picric acid university of wisconsin. Aug 29, 2018 picric acid is highly reactive with a wide variety of materials e. Picric acid is acutely hazardous to the skin as a corrosive and irritant.
Label containers of picric acid or picric acid solutions with the date received and date opened. Read the full msds for more details before handling. Data on the potential for picric acid to cause cancer, birth defects or reproductive effects in laboratory animals were not available. Picric acid forms salts with manymetals some of which are rather sensitiv nickel, copper, etc. Safety data sheet according to federal register vol. Perform a hazardous waste determination on mixtures. You will need adobe acrobat reader in order to see these. Onestep synthesis of picric acid from phenol article pdf available in organic preparations and procedures international 492. Section xiii disposal considerations local governments may restrict the amounts of picric acid that may be flushed down the drain. The federally mandated osha hazardous communication standard states that workers must have access to relevant sdss and be educated on their contents and application in a format they can understand. Dry mixtures of picric acid and aluminum powder are inert, but the addition of water causes ignition after a delay dependent upon the quantity added.
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